Alcohol and Amoxicillin: Is It Safe to Mix Them?

Medically Reviewed:
Dr. Randy Gelow, MD, FASAM
Ray Hamilton, DNP, PMHNP-BC, FNP-C
Last Updated: July 26, 2025

When you’re prescribed antibiotics like amoxicillin, it’s natural to wonder what lifestyle choices might affect your recovery. One of the most common questions doctors hear is: Can you mix alcohol and amoxicillin?

Moderate alcohol intake doesn’t directly interfere with how amoxicillin works. However, taking amoxicillin and drinking alcohol can still come with risks. Some risks are subtle, and some are more serious.

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What is Amoxicillin and How Does It Work?

Amoxicillin is a common antibiotic doctors use to fight infections caused by bacteria. It works by stopping the growth of bacteria, which helps your immune system clear the infection more quickly. It’s effective, generally well-tolerated, and prescribed to both adults and children.

People often take amoxicillin for things like:

  • Strep throat
  • Sinus infections
  • Urinary tract infections (UTIs)
  • Ear infections
  • Bronchitis
  • Skin infections

Amoxicillin doesn’t work on viruses. So, it won’t help with things like the flu or a cold. It is essential to take it exactly as prescribed, even if you start feeling better. This is to ensure that all the bacteria are killed and the infection doesn’t return stronger.

Unlike certain antibiotics, like metronidazole or cefotetan, amoxicillin does not interact with alcohol. But that doesn’t mean it is safe to mix the two.

Can You Drink Alcohol While Taking Amoxicillin?

Can you mix alcohol and amoxicillin? Alcohol does not directly cancel the effectiveness of amoxicillin. So technically, combining amoxicillin 500 mg and alcohol (small amounts) is not likely to cause a serious medical issue. However, mixing amoxicillin and alcohol is not always a good idea.

Side Effects of Amoxicillin

Amoxicillin already comes with possible side effects:

  • Nausea vomiting
  • Diarrhea
  • Dizziness

Combining amoxicillin and alcohol can increase the risk of worsening the side effects. You may feel extra tired, dizzy, or more likely to experience gastrointestinal side effects.

When you are feeling sick enough to need antibiotics, your body probably needs rest and not alcohol. So, it is best to avoid alcohol. In some cases, your doctor prescribes amoxicillin alongside other medications, and alcohol consumption could interfere with those.

What are the Side Effects?

A small drink is unlikely to cause harm. But it’s safest to wait until you’ve finished your medication and you’re feeling better. Alcohol may worsen some of amoxicillin’s side effects or lead to complications. These can include:

  1. Alcohol can intensify side effects. Amoxicillin may cause nausea, dizziness, or stomach upset. Alcohol can worsen all of these and make you feel much worse while you’re trying to get better.
  2. It can increase your blood pressure.
  3. It can delay your recovery. Consuming alcohol while sick can weaken your immune system and interfere with your body’s ability to fight off infection, slowing down the healing process, even if amoxicillin is doing its job. Alcohol can also make your recovery more complicated and more uncomfortable.
  4. Liver stress. The liver processes both alcohol and amoxicillin. Drinking may overload your liver, especially if you’re taking other medications too.
  5. Dehydration and fatigue. Alcohol is a diuretic and can cause dehydration, which can make infection symptoms (like fever or fatigue) feel worse.

If you have already experienced side effects from amoxicillin, alcohol may make them more intense or more complicated to manage. In people with weakened immune systems or with allergic reactions to amoxicillin, the consequences can be more severe.

One overlooked consequence of mixing alcohol and antibiotics is the risk of forgetting to take your medication. Skipping doses due to hangovers or illness from drinking can lead to antibiotic resistance. This can make the infection harder to treat and possibly require more potent medications later on.

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Why Do People Still Drink While on Antibiotics?

Doctors often advise against taking amoxicillin and drinking alcohol. However, combining alcohol and amoxicillin is common to many. One reason is that some folks don’t realize there can be side effects.

There are a few common misconceptions:

  1. “It’s just one drink. It won’t hurt.” While one drink might not cause immediate harm, any amount can still interfere with your body’s healing process, especially when you’re fighting off infection.
  2. “My doctor didn’t say anything.” Not all healthcare providers explicitly warn against alcohol with every prescription, especially for low-risk antibiotics like amoxicillin. But that doesn’t mean it’s risk-free.
  3. “I’ve done it before and felt fine.” Your body’s tolerance can vary based on factors such as your health, hydration, liver function, and other medications. Just because you felt fine once doesn’t mean it’s always safe.

But just because it doesn’t cause an obvious problem right away doesn’t mean it’s harmless. People often drink while on antibiotics because of habit, lack of information, or social pressure—but it’s always safer to wait until treatment is finished.

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Your Relationship with Alcohol

Drinking while sick can make things worse and slow your recovery. Suppose you’re mixing alcohol with medications, and these include amoxicillin. In that case, it may be time to take a closer look at your relationship with alcohol.

While occasional drinking might seem harmless, using alcohol, even during illness or antibiotic treatment, can be a sign of deeper dependence. At our rehab center, we understand how alcohol use can interfere with not just medications, but with your health, healing, and quality of life.

If you’re struggling to stop drinking, even when you know it’s not safe, we’re here to help. Reach out today! Contact The Hope House at (480)-447-4252. You may also email us at contact@thehopehouse.com or visit us at 28901 N 11th St., Scottsdale, AZ 85262.

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