Learn What Are the Signs of Oxycodone Overdose

Medically Reviewed:
Dr. Randy Gelow, MD, FASAM
Ray Hamilton, DNP, PMHNP-BC, FNP-C
Last Updated: July 19, 2025

Oxycodone is a strong opioid used to treat chronic pain and other painful medical conditions. While it offers powerful pain relief, misuse can lead to dangerous consequences. Recognizing the signs of an oxycodone overdose may be critical to saving a life—your own or someone else’s.

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The Effects of Oxycodone

Oxycodone alters how the brain responds to pain by acting on opioid receptors. It often brings relaxation and euphoria, which is why it’s prone to misuse. However, it also slows breathing and heart rate.

The side effect of slowed breathing becomes life-threatening when large doses are taken or when combined with alcohol or other drugs. This greatly increases the risk of overdose—including death.

Oxycodone Overdose Symptoms

Understanding oxycodone overdose symptoms is essential. Overdose occurs when the nervous system is overwhelmed, usually by taking too much or mixing with other substances.

Common signs of an overdose include:

  • Shallow or stopped breathing
  • Tiny, pinpoint pupils
  • Blue lips or fingers
  • Cold, clammy skin
  • Vomiting or gurgling
  • Unconsciousness or extreme drowsiness

These are classic signs of opioid overdose and require urgent action.

How to Tell If Someone Overdosed on Oxycodone

If you’re unsure how to tell if someone overdosed on oxycodone, check for responsiveness. Are they awake when spoken to or gently shaken? Are they breathing normally?

If not, act fast. These symptoms of oxycodone overdose mean the person may be in danger.

What to Do in Case of Opioid Overdose

Call emergency medical services immediately—do not assume they’ll “sleep it off.” If you’re in a country where 911 is not available, contact your local emergency number right away.

Steps to take:

  • Call 911 or local emergency services
  • Administer naloxone if you have it (nasal spray or injection)
  • Perform rescue breathing if needed
  • Stay with the person until help arrives

Knowing what to do in case of opioid overdose can save a life.

Responding quickly to opioid overdose saves lives. Know what steps to take in an emergency.

The Dangers of Oxycodone Abuse

Oxycodone abuse includes using it without a prescription or mixing it with substances like alcohol. These behaviors increase the risk of overdose. Drinking alcohol with prescription drugs like oxycodone intensifies sedation and breathing problems.

In fact, opioid overdose has become a leading cause of death in the United States, with prescription drugs like oxycodone playing a major role. Misuse can also lead to withdrawal, addiction, and repeat overdoses. Recognizing the dangers of oxycodone early can prevent life-threatening outcomes.

Opioid Overdose Treatment and Prevention

Emergency opioid overdose treatment often starts with naloxone and continues with medical support. Recovery includes:

  • Detox
  • Counseling
  • Opioid medications like buprenorphine
  • Ongoing overdose prevention planning

To reduce the risk of overdose:

  • Take only as prescribed
  • Don’t mix with alcohol or sedatives
  • Keep prescription opioids secure
  • Learn to use naloxone nasal spray
  • Talk to your health care provider about risks

When to Get Help

Warning signs of misuse include:

  • Needing more for the same effect
  • Taking higher doses than prescribed
  • Combining opioids with alcohol or other prescription drugs

If you see these signs, reach out for help. Early action can stop the cycle of misuse and prevent future overdoses.

Support is here—for you or someone you love. Start your path to safe, lasting recovery.

Knowing the Signs Can Save a Life

Oxycodone overdose symptoms can be deadly, but they are also preventable. Whether you’re taking the medication or caring for someone who is, recognizing signs of an overdose and acting quickly is key.

At HART Rehab, we help individuals recover from opioid drugs and reclaim their lives. Our personalized programs support safer pain management and long-term wellness.

Learn how to prevent an opioid overdose. Real advice from experts and lived experience.